Googles dilemma Case Study Example | Topics and Well Written Essays - 500 words

Googles dilemma - Case Study Example When Larry Paige and Sergie Brian hit upon the idea in 1998, the concept of search engine was still vague. Thus, Google’s success lies in tapping the search engine space and as it grew exponentially; it had to evolve into some kind of structured organization if it had to maintain its astounding growth rate. Summary of the situation: The tile of the case about the â€Å"dilemma† faced by Google is how to motivate and energize its young staff while maintaining a semblance of formalized structures. The key is to incubate new ideas in an organization while having some sort of bureaucratic structures in place to sustain its growth. SWOT The strength of Google is innovation and the workforce that prides itself on being â€Å"geeky† but resents formalized structures. Google derives its main strength from the way in which employees use their spare time to sound off on potential ideas that can be the â€Å"next big thing†. The weakness of Google lies in the way in which it is grappling with establishing formal governance structures. This is a classic dilemma faced by many technology companies: How to grow without making the workforce feel that are part of an â€Å"impersonal† and â€Å"mechanical† organization. Google’s opportunity is the ever growing web applications market that has seen it grow at an annualized rate of around 30% over the last few years. The vitality and creativity of the workforce is another area of opportunity. Finally, the threat to Google is two-fold: potential start-ups like cuil.com that were started by ex-Google employees and can eat into its search engi ne market. Second, the rising headcount that now stands at over 6,000 can make it a victim of its own success. Recommendations: it is recommended that Google’s management team inculcate a spirit of structure and formalized communication channels instead of the â€Å"college† atmosphere that

Gel electrophoresis Essay Example for Free

Gel electrophoresis Essay The explosion of molecular biology techniques that began in the mid-1970s (and continues today) has provided tools to examine the physical structure of DNA, its nucleotide sequence and how genes are read and regulated. One key tool is the ability to visualize DNA molecules and determine their length by using a technique called gel electrophoresis. Introduction to gel electrophoresis In gel electrophoresis, DNA fragments move through a porous matrix made of agarose, a gelatin-like substance purified from seaweed. The agarose is melted like Jell-O and then poured into a plastic tray to harden into a slab called a gel. A plastic comb inserted at one end while the gel is hardening forms wells where DNA samples can be placed. The DNA is mixed with a loading buffer that contains glycerol—this makes it heavier than water, so it will sink to the bottom of the well. The gel is then covered with a buffer solution that can carry electric current, and electrodes are placed at each end of the gel and connected to a power supply. Because DNA is negatively charged (each nucleotide has a negatively charged phosphate attached to it), it will move toward the positive electrode. Larger molecules move through the agarose more slowly, while smaller ones  can slip through the pores faster. So, the fragments wind up arranged in order according to size, with the smaller ones having moved farther toward the positive pole. Figure 47 shows an example. Because the DNA is invisible, the loading buf fer also contains two dy e s : bromophenol blue (a small dye molecule that behaves like a DNA fragment about 600 bases long) and xylene cyanol (a larger dye that acts like a DNA fragment of about 4000 bases). These dyes form lines that give you an idea of how far your DNA has moved. Some loading buffers also have a third dye, behaving like a very small DNA molecule (50 bases or so). As the DNA migrates, the different fragments will form bands; each band is composed of many identical copies of a particular-size piece of DNA (you can’t do gel electrophoresis with one DNA molecule: you need millions or billions of identical molecules). The last step is to make the DNA bands visible, using a fluorescent molecule that inserts between the bases in the DNA helix. We use a commercial loading buffer called EZ-Vision which includes the fluorescent molecule, so the gel is already stained when it’s done running. Another method is to soak the gel in ethidium bromide after running it. Either way, the bands can be seen using ultraviolet light and photographed to make a permanent record. Sample preparation Of course, gel electrophoresis requires some kind of DNA sample—a plasmid, a PCR product, a segment of a chromosome, etc. If the molecule is circular, enzymes are used to cut the DNA (see the section on restriction digestion, page 87), because circular molecules can be either tightly or loosely coiled and don’t wind up at the same place on a gel as a linear molecule of the same size. Whatever your sample is, it must be mixed with loading buffer (containing glycerol and dyes, as described above) before electrophoresis. Add a volume of loading buffer equal to 1/5 the volume of your sample and mix it well before loa

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Page 1 of 3 3803 The Treaty of Versailles. (buy this paper) This eleven-page undergraduate paper discusses the Treaty of Versailles which ended the First World War in terms of the Allies' desire for vengeance, the treaty's punishing territorial provisions, the unrealistic war reparations payments demanded of Germany, and the dire consequences these had upon chances for future peace. 11 pgs. Bibliography lists 5 sources. Filename: 3803 Treaty of Versailles.doc Price: $98.45 3922 The Causes of World War One. (buy this paper) This paper evaluates the causes of the First World War. It shows how scholars have pointed to the forces of nationalism, militarism and imperialism to explain the origins of the conflict. The war was certainly caused by the collision of interests between imperial powers. Overall, the paper reveals that the historiographical debate surrounds the issue of whether it was individual events or underlying forces that caused the war. 6 pgs. Bibliography lists 3 sources. Filename: 3922 World War One.doc Price: $ 53.70 6815 "In viewing the possible impact of the United States towards the War effort "over there", did the United States turn the tide of battle, that is, in all facets, economically, and militarily, did the impact of the United States entry into World War I enable the allies to achieve victory---YES OR NO?" (buy this paper) This is a 6-page paper in MLA style that states that World War I was won on the basis of the entrance of the Americans who through their military and economic help changed the tide of the war. 6 pgs. Bibliography lists 7 sources. Filename: 6815 US War Efforts.doc Price: $53.70 10247 Influence on Public Opinion in World War One. (buy this paper) This 4-pages undergraduate paper examines the role played by intellectuals and of propaganda in the World War I era. 4 pgs. Bibliography list 3 sources. Filename: 10247 Public Opinion War.doc Price: $35.80 2228 The Bombing of Hiroshima and Nagasaki. (buy this paper) This paper looks at the bombing by the Americans on Hiroshima and Nagasaki as an inevitable decision to avoid a long drawn out war with Japan. Essentially, the decision to bomb was the lesser of two evils. 10.5 pgs. 21 f/c. 10b. Filename: 2228 Bombing Hiroshima Nagasaki.doc Price: $89.50 2079 The American Decision to Use a Nuclear Weapon on Hiroshima. (buy this paper) 13 pgs. 17 f/c. 12b. Filename: 2079 American Decision Nuclear.

Environment Protection Essay

Televison has brought great changes to the way many children spend their leisure time. While some of these changes have been beneficial, other have had a harmful effect. To what extent do you agree or disagree Most children nowadays, watch television as part of their leisure time. It is found that watching television for young children has both its advantages and disadvantages. A child can learn quite a lot of useful things and entertain himself by watching television but he can also become addicted to watching television and take bad things from it. Television offers programs which can learn the child good qualities that should be in him as he grows up. this includes educational programs and cartoons. A child can learn languages, math, to depend on himself, take actions, work harder, how to reach goals and others. For example, a cartoon I saw when I was young called captain Majid’ is based on a football player named Majid where hes the captain of his team and he tries his best to get goals for his team. Other players pass the ball to him and he runs with the ball, not afraid of anyone, trusting himself and makes the right shot at the goal keeper of the other team which results in an extra goal for his team. I learned from this how to be confident in myself and how to always try hard until I reach my goal. Television also can bring harmful effects to children. Children can learn bad words or to be violent. The child himself can also become addicted and this will prevent him from doing other important activities he should be doing. For Instance, a cartoon called tom and jerry, which I loved to watch when I was young, is very addictive, is based on a cat and mouse fight where the cat always tries to catch the mouse. In most cases the cat fails to do this, however. you learn violence from this, in confidence and inability to try to reach your goal. In conclusion, Televison can lead to benefits or bad effects on children depending on hoe its used. Parents should restrict their children to see only programs that that can lead to better improvements in their children and their time spent on television, hoping that their children become good people who benefit their community and the world.

Diapedesis

The article describes that diapedesis is the movement of white blood cells called leukocytes from circulating blood stream into areas of the body tissue where there is ongoing inflammatory reaction in response to cellular injury. The article evaluates the present facts on diapedesis and itemized several unresolved issues yet to be studied for perfect understanding of the biology of diapedesis. Though the author notes that compressive definition is poorly defined in scientific study, he however noted that diapedesis is technically accepted as transmigration of leukocyte between â€Å"endothelial cell-cell junctions† (Dejana, 106).Other upcoming research also has it that it can migrate through the endothelial cell. The articles points out literature reviews by several other authors to justify the possibility of transcellular and paracellular movements of leukocyte through the endothelial cells. The clarity from these two propositions is necessary to assist scientists in understa nding the arrangement and nature of proteins found along the pathway.This will help modulate the process and achieve desired aim(s) in clinical practice. The findings thus hold that leukocytes cross by biochemical interaction with molecular adhesive proteins at that line the endothelial junctions (Dejana 106). Some of the notable molecules are ICAM-1 and VCAM-1. Considering the intracellular movement, the article discussed that leukocyte can evade killing by the lysosome unlike some pathogen, to cross over into the tissue undergoing inflammation.Subsequent to the attachment of leukocyte to the ICAM-1 or VCAM-1, there is reshaping of the cytoskeleton of the cell to form transmissible cup like structure. The article raises several questions like what factors initiate the cup like formation, and which proteins play role in cytoskeletal conformational change. Answers to several questions the author raises are fundamental to scientific breakthrough in maneuvering process of inflammation to less harmful and more beneficial process in diseases e. g. cancer and organ infectious and toxic exposure. Reference Dejana Elisabetha. The Transcellular Railway: insights into leukocyte. Natural Cell Biology (2008) , Retrieved: April 24,2009. 105 – 107. Site Available at: